[ en-doh-pep-ti-deys, -deyz ]
/ ˌɛn doʊˈpɛp tɪˌdeɪs, -ˌdeɪz /

noun Biochemistry.

an enzyme that catalyzes the cleavage of a polypeptide or protein at interior positions of the amino acid chain.

Origin of endopeptidase

First recorded in 1935–40; endo- + peptidase
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

British Dictionary definitions for endopeptidase

/ (ˌɛndəʊˈpɛptɪˌdeɪz) /


any proteolytic enzyme, such as pepsin, that splits a protein into smaller peptide fragmentsAlso called: proteinase Compare exopeptidase
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Medicine definitions for endopeptidase

[ ĕn′dō-pĕptĭ-dās′, -dāz′ ]


Any of a large group of enzymes that catalyze the hydrolysis of peptide bonds in the interior of a polypeptide chain or protein molecule.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.