[en-doh-pep-ti-deys, -deyz]

noun Biochemistry.

an enzyme that catalyzes the cleavage of a polypeptide or protein at interior positions of the amino acid chain.

Nearby words

  1. endomysium,
  2. endoneuritis,
  3. endoneurium,
  4. endonuclease,
  5. endoparasite,
  6. endopericarditis,
  7. endoperidium,
  8. endoperimyocarditis,
  9. endoperitonitis,
  10. endophagous

Origin of endopeptidase

First recorded in 1935–40; endo- + peptidase

Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

British Dictionary definitions for endopeptidase



any proteolytic enzyme, such as pepsin, that splits a protein into smaller peptide fragmentsAlso called: proteinase Compare exopeptidase
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Medicine definitions for endopeptidase


[ĕn′dō-pĕptĭ-dās′, -dāz′]


Any of a large group of enzymes that catalyze the hydrolysis of peptide bonds in the interior of a polypeptide chain or protein molecule.

The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.