estradiol
Americannoun
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Biochemistry. an estrogenic hormone, C 18 H 24 O 2 , produced by the maturing Graafian follicle, that causes proliferation and thickening of the tissues and blood vessels of the endometrium.
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Pharmacology. a commercial form of this compound, obtained from the urine of pregnant humans and mares or synthesized, used in the treatment of estrogen deficiency and certain menopausal and postmenopausal conditions.
noun
Etymology
Origin of estradiol
1930–35; estra- (combining form representing estrin ) + di- 1 + -ol 1
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
Demand is up for several reasons; more doctors are prescribing the transdermal bioidentical estradiol, and the manufacturing process for patches is more labor-intensive and time-consuming than making pills.
From MarketWatch • May 12, 2026
Bioidentical estradiol, which is the most common form used today, was not included in the WHI.
From MarketWatch • May 12, 2026
The demand for estradiol patches—which deliver steady doses of estrogen—is soaring as women seek relief from symptoms of menopause and perimenopause.
From The Wall Street Journal • Feb. 13, 2026
Felicia Zigman, 54, who has been using estradiol patches for about nine months, said that a pharmacist told her to talk to her doctor about increasing her dosage, given the shortage of starting-dosage patches.
From The Wall Street Journal • Feb. 7, 2026
A new study led by Johns Hopkins Medicine takes a closer look at whether sex hormones, including testosterone and estradiol, may help explain why these risks vary.
From Science Daily • Feb. 4, 2026
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
