fluxe is not in our dictionary (yet). Here's what it could mean:

Example Sentences

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They had amongst them ye fluxe, and allso wante of fresh water; so as it is hear rather wondred at yt so many are alive, then that so many are dead.

From Bradford's History of 'Plimoth Plantation' From the Original Manuscript. With a Report of the Proceedings Incident to the Return of the Manuscript to Massachusetts by Bradford, William

Tobias Atkins the gunners boy died of the fluxe, who was buried the 6. day 2. miles to the Southward of the Castle of Derbent, where the Armenian Christians do vsually bury their dead.

From The Principal Navigations, Voyages, Traffiques and Discoveries of the English Nation — Volume 04 by Hakluyt, Richard