frameshift

American  

[freym-shift] / ˈfreɪmˌʃɪft /

noun

Genetics.

1. the addition or deletion of one or more nucleotides in a strand of DNA, which shifts the codon triplets of the genetic code of messenger RNA and causes a misreading during translation, resulting in an aberrant protein and therefore a mutation.

---

frameshift Scientific  

/ frām′shĭft′ /

1. Relating to a mutation that occurs when one or two nucleotides are added or deleted, with the result that every codon beyond the point of insertion or deletion is read incorrectly during translation.

2. See more at point mutation

---

Etymology

Origin of frameshift

frame + shift

Compare meaning

How does frameshift compare to similar and commonly confused words? Explore the most common comparisons:

• point mutation vs. frameshift

Example Sentences

Frameshift mutations usually cause multiple amino acid changes, increasing chances that a new protein will form, leading to radically different characteristics in the offspring.

From Textbooks • Jun. 9, 2022

Frameshift mutations may cause a different amino acid to be placed at a specific location, causing small changes in a protein.

From Textbooks • Jun. 9, 2022

Frameshift mutations cause multiple amino acid differences in a protein, leading to small changes in the protein.

From Textbooks • Jun. 9, 2022

Frameshift mutations can change every amino acid that follows the point of the mutation.

From Textbooks • Jan. 1, 2018