glucocorticoid

American  

[gloo-koh-kawr-ti-koid] / ˌglu koʊˈkɔr tɪˌkɔɪd /

noun

Biochemistry.

1. any of a class of steroid hormones that are synthesized by the adrenal cortex of vertebrates and have anti-inflammatory activity.

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glucocorticoid British  

/ ˌɡluːkəʊˈkɔːtɪˌkɔɪd /

noun

1. any of a class of corticosteroids that control carbohydrate, protein, and fat metabolism and have anti-inflammatory activity

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Etymology

Origin of glucocorticoid

1945–50; gluco- + cortic(o)- ( def. ) + -oid; cf. corticosteroid

Example Sentences

See Examples For:

glucocorticoid

FOXA1 is known to have cancer-promoting properties, which is why the researchers assumed that inhibiting its activity would limit the development of glucocorticoid receptor-mediated drug-resistant prostate cancer.

From Science Daily ● Apr. 10, 2024

"This study showed that the glucocorticoid receptor can only use regulatory regions that are already active in prostate cancer cells," says Doctoral Researcher Laura Helminen of the University of Eastern Finland.

From Science Daily ● Apr. 10, 2024

Glucocorticoids regulate vital biological processes by affecting gene encoding through a DNA-binding transcription factor, namely the glucocorticoid receptor.

From Science Daily ● Apr. 10, 2024

However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer.

From Science Daily ● Apr. 10, 2024

Surprisingly however, the effect was exactly the opposite: inhibiting the activity of FOXA1 further increased the activity of the glucocorticoid receptor -- and the development of drug resistance.

From Science Daily ● Apr. 10, 2024