glucocorticoid

American  

[gloo-koh-kawr-ti-koid] / ˌglu koʊˈkɔr tɪˌkɔɪd /

noun

Biochemistry.

1. any of a class of steroid hormones that are synthesized by the adrenal cortex of vertebrates and have anti-inflammatory activity.

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glucocorticoid British  

/ ˌɡluːkəʊˈkɔːtɪˌkɔɪd /

noun

1. any of a class of corticosteroids that control carbohydrate, protein, and fat metabolism and have anti-inflammatory activity

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Etymology

Origin of glucocorticoid

1945–50; gluco- + cortic(o)- ( def. ) + -oid; cf. corticosteroid

Example Sentences

In other words, glucocorticoid receptor-mediated drug resistance emerges through these regulatory regions, and by affecting the activity of these areas, the harmful effects of glucocorticoids in prostate cancer could be prevented.

From Science Daily • Apr. 10, 2024

Ultimately, inhibiting the activity of both the androgen and the glucocorticoid receptor was found to be primarily due to the limitation of FOXA1 activity.

From Science Daily • Apr. 10, 2024

The activity of the glucocorticoid receptor in regulatory regions can, however, be influenced in drug-resistant prostate cancer through an alternative pathway.

From Science Daily • Apr. 10, 2024

However, recent studies have shown that the glucocorticoid receptor also has an oncogenic, or cancer-promoting, effect in cancers like breast and prostate cancer.

From Science Daily • Apr. 10, 2024

FOXA1 is known to have cancer-promoting properties, which is why the researchers assumed that inhibiting its activity would limit the development of glucocorticoid receptor-mediated drug-resistant prostate cancer.

From Science Daily • Apr. 10, 2024