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glycolysis

American  
[glahy-kol-uh-sis] / glaɪˈkɒl ə sɪs /

noun

Biochemistry.
  1. the catabolism of carbohydrates, as glucose and glycogen, by enzymes, with the release of energy and the production of lactic or pyruvic acid.


glycolysis British  
/ ɡlaɪˈkɒlɪsɪs /

noun

  1. biochem the breakdown of glucose by enzymes into pyruvic and lactic acids with the liberation of energy

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

glycolysis Scientific  
/ glī-kŏlə-sĭs /
  1. The process in cell metabolism by which carbohydrates and sugars, especially glucose, are broken down, producing ATP and pyruvic acid.

  2. See more at cellular respiration


Etymology

Origin of glycolysis

First recorded in 1890–95; glyco- + -lysis

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Explanation

Glycolysis is a series of chemical reactions that happen inside a cell. During glycolysis, a molecule of glucose is broken down into two molecules of pyruvate. In certain cells, energy is obtained from glucose through glycolysis, which breaks the sugar into two pieces that can be used for cellular respiration. Almost every living organism has cells that undergo glycolysis, even the ones that don't use oxygen. Scientists' understanding of this process started with the 19th-century wine industry's quest to learn why some wines ferment into alcohol and others turn bitter. The word glycolysis was coined in 1891, from glyco-, "sugar," and -lysis, "dissolving."

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Vocabulary lists containing glycolysis

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Cancer cells are known to alter their metabolism, relying heavily on aerobic glycolysis to rapidly generate energy.

From Science Daily Mar. 2, 2026

"This is an odd adaptation but allows them to perform anaerobic glycolysis," Hadj-Moussa explained.

From Salon Apr. 20, 2025

The reactivation of melanin synthesis forces the melanoma cell to reduce glycolysis, the process of converting sugar to energy, which is believed to be the mechanism for its anti-cancer effect.

From Science Daily Jun. 18, 2024

If glycolysis is interrupted, these cells would eventually die.

From Textbooks Apr. 25, 2013

But even bacteria do anaerobic glycolysis, which is why apples rot: lunchtime for the microbes.

From "Cosmos" by Carl Sagan

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