agranulocytosis

American  

[uh-gran-yuh-loh-sahy-toh-sis] / əˌgræn jə loʊ saɪˈtoʊ sɪs /

noun

Pathology.

1. a serious, acute blood disease, sometimes related to drug or radiation therapy, characterized by extreme leukopenia, fever, and ulcerations of the mucous membranes.

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agranulocytosis British  

/ əˌɡrænjʊləʊsaɪˈtəʊsɪs /

noun

1. a serious and sometimes fatal illness characterized by a marked reduction of leucocytes, usually caused by hypersensitivity to certain drugs

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Etymology

Origin of agranulocytosis

First recorded in 1925–30; a- ⁶ + granulocyte + -osis

Example Sentences

See Examples For:

agranulocytosis

But in the 1960s, physicians linked medically prescribed potassium perchlorate to a number of deaths by aplastic anemia and severe agranulocytosis, two blood disorders.

From Slate ● Apr. 7, 2015

Now scientists are exploring an entire spectrum of what Dr. Steven Paul, vice president for central-nervous-system research at Eli Lilly, calls "Clozaril wannabes" that they hope will work as well without triggering agranulocytosis.

From Time Magazine Archive

There have been four confirmed cases of agranulocytosis, with one death.

From Time Magazine Archive

This form of blood disease, known as agranulocytosis or leukopenia, leaves the body at the mercy of any bacteria which may enter the bloodstream.

From Time Magazine Archive

But Clozaril has a major drawback: a life-threatening side effect called agranulocytosis, a drastic drop in white blood cells that requires patients to undergo expensive weekly blood monitoring.

From Time Magazine Archive