- a son of one's nephew or niece; grandnephew.
Origin of great-nephew
First recorded in 1575–85
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2018
Examples from the Web for great-nephew
Jarvis Barrow, that's a strong witness, should have had another sort of great-nephew!Foes
If only Percy had been older and had a son, he could settle the money upon his great-nephew.War-time Silhouettes
The thought that his great-nephew and his niece had actually slept there horrified him.The Matador of the Five Towns and Other Stories
Her last act was to appoint Biren regent during the infancy of her great-nephew.
She had adopted her great-nephew Ronald while he was still quite a baby, and he could remember no other home than hers.The School by the Sea
- a son of one's nephew or niece; grandson of one's brother or sister