the bubonic plague that occurred in London in 1665 and killed about 15 percent of the city's population.
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How to use Great Plague in a sentence
The Great Plague of this and the subsequent year broke out at St. Giles, London.The Every Day Book of History and Chronology | Joel Munsell
Nine years later there followed the Great Plague, of which Boccaccio has left us so terrible an impression.Florence and Northern Tuscany with Genoa | Edward Hutton
In 1563 he observed a conjunction of Jupiter and Saturn, the precursor, and cause as he thought it, of the Great Plague.Pioneers of Science | Oliver Lodge
When the Great Plague broke out he remained at his house in Walbrook, and gave advice to all who sought it.
One of the most remarkable facts in connection with the Great Plague is this—that it was the last in England.