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Synonyms

guinea pig

American  

noun

  1. a short-eared, tailless rodent of the genus Cavia, usually white, black, and tawny, commonly regarded as the domesticated form of one of the South American wild species of cavy: often used in scientific experiments or kept as a pet.

  2. Informal. the subject of any sort of experiment.

    I've volunteered as a guinea pig in several clinical trials.


guinea pig British  

noun

  1. a domesticated cavy, probably descended from Cavia porcellus, commonly kept as a pet and used in scientific experiments

  2. a person or thing used for experimentation

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of guinea pig

First recorded in 1655–65

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

As he buttoned up a professional baseball uniform for the first time in his life, he understood that he was becoming the guinea pig in an experiment that has the whole industry watching.

From The Wall Street Journal • Nov. 25, 2025

"It just feels as if mum was a guinea pig, which is not nice to think about."

From BBC • Jun. 4, 2025

His lead, Pattinson’s Mickey Barnes, is a dopey, instantly lovable voluntary “Expendable,” jettisoned into space to be a human guinea pig who will be pivotal in colonizing a faraway planet.

From Salon • Mar. 7, 2025

Alec spent his teens and early 20s helping out around Erewhon, a fast-tracked corporate education that included partaking in the human guinea pig sample sessions led by his mother.

From Los Angeles Times • Jun. 2, 2024

I wonder if my mom will let me get another guinea pig, if I ask her.

From "Hello, Universe" by Erin Entrada Kelly