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• mayo
  mayo

  noun

  mayonnaise.
• Mayo
  Mayo

  noun

  Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

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Slang dictionary results for mayo.

mayo

¹ American  

[mey-oh] / ˈmeɪ oʊ /

noun

Informal.

1. mayonnaise.

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Mayo ² American  

[mey-oh] / ˈmeɪ oʊ /

noun

1. Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

2. a county in NW Connaught province, in the NW Republic of Ireland. 2,084 sq. mi. (5,400 sq. km). Castlebar.

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Mayo ¹ British  

/ ˈmeɪəʊ /

noun

1. a county of NW Republic of Ireland, in NW Connacht province, on the Atlantic: has many offshore islands and several large lakes. County town: Castlebar. Pop: 117 446 (2002). Area: 5397 sq km (2084 sq miles)

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Mayo ² British  

/ ˈmeɪəʊ /

noun

1. a family of US medical practitioners. They pioneered group practice and established (1903) the Mayo Clinic in Rochester, Minnesota. Foremost among them were William Worrall Mayo (1819–1911), his sons William James Mayo (1861–1939) and Charles Horace Mayo (1865–1939), and Charles's son, Charles William Mayo (1898–1968)

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Usage

What else does mayo mean? Typically, mayo is short for mayonnaise, a classic condiment made of oil, vinegar, and egg yolks. When not, it can also be used as offensive language against white people or a slang term for drugs. Content warning: the following article deals with content related to illicit drugs and offensive and disparaging language.

Etymology

Origin of mayo

By shortening; cf. -o

Example Sentences

See Examples For:

mayo Mayo

Unlike bleach and wipes, a product made of buttermilk and mayo is not exactly designed for mass consumption.

From The Wall Street Journal ● Jul. 17, 2026

You can also try making cottage cheese mayonnaise, which is significantly easier to make than traditional mayo.

From Salon ● May 24, 2026

Chia seeds are a nutrient-dense replacement for eggs, meaning you can make plant-based cookies and even plant-based mayo.

From Salon ● Mar. 31, 2026

I made a mayo line because: there’s such a delta between a sandwich made in the average American home and one made in great sandwich shops.

From The Wall Street Journal ● Feb. 11, 2026

“Why didn’t you just talk to me? Tell me about the mayo and Cotton Swab instead of sneaking?”

From "Witchlings" by Claribel A. Ortega

Mayo reports to Uday Ruddarraju, who was promoted this month to become OpenAI’s chief technology officer of computing capacity.

From The Wall Street Journal ● Jul. 22, 2026

“There’s a couple of reasons,” Dr. Michael Joyner, a specialist in the physiology of elite athletes at the Mayo Clinic, said of the growing lifespan of soccer players.

From Los Angeles Times ● Jul. 15, 2026

The first ever commercial wind farm on the island of Ireland - Bellacorrick in County Mayo - was decommissioned at the start of the year.

From BBC ● Jul. 4, 2026

The study, led by Mayo Clinic nephrologist Fouad Chebib, M.D., was published in the Journal of Clinical Investigation.

From Science Daily ● Jun. 17, 2026

“Why are we going to the Mess? Are you going to let me steal some extra mayonnaise packets? Mayo counts as, like, what? Eggs?”

From "Internment" by Samira Ahmed