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• mayo
  mayo

  noun

  mayonnaise.
• Mayo
  Mayo

  noun

  Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

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Slang dictionary results for mayo.

mayo

¹ American  

[may-oh] / ˈmeɪ oʊ /

noun

Informal.

1. mayonnaise.

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Mayo ² American  

[may-oh] / ˈmeɪ oʊ /

noun

1. Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

2. a county in NW Connaught province, in the NW Republic of Ireland. 2,084 sq. mi. (5,400 sq. km). Castlebar.

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Mayo ¹ British  

/ ˈmeɪəʊ /

noun

1. a county of NW Republic of Ireland, in NW Connacht province, on the Atlantic: has many offshore islands and several large lakes. County town: Castlebar. Pop: 117 446 (2002). Area: 5397 sq km (2084 sq miles)

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Mayo ² British  

/ ˈmeɪəʊ /

noun

1. a family of US medical practitioners. They pioneered group practice and established (1903) the Mayo Clinic in Rochester, Minnesota. Foremost among them were William Worrall Mayo (1819–1911), his sons William James Mayo (1861–1939) and Charles Horace Mayo (1865–1939), and Charles's son, Charles William Mayo (1898–1968)

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Usage

What else does mayo mean? Typically, mayo is short for mayonnaise, a classic condiment made of oil, vinegar, and egg yolks. When not, it can also be used as offensive language against white people or a slang term for drugs. Content warning: the following article deals with content related to illicit drugs and offensive and disparaging language.

Etymology

Origin of mayo

By shortening; cf. -o

Example Sentences

See Examples For:

mayo Mayo

Unlike bleach and wipes, a product made of buttermilk and mayo is not exactly designed for mass consumption.

From The Wall Street Journal ● Jul. 17, 2026

You can also try making cottage cheese mayonnaise, which is significantly easier to make than traditional mayo.

From Salon ● May 24, 2026

The swap is simple: use yogurt in place of some or all of the mayo.

From Salon ● Apr. 28, 2026

A single distribution network that served them with small packets of shampoo as well as jars of mayo made sense.

From The Wall Street Journal ● Mar. 20, 2026

Trey licks mayo from his fingers, chomps on the last piece of bread.

From "Black Brother, Black Brother" by Jewell Parker Rhodes

In a post on X, Wiles said her pathology tests "came back clear" after a visit to the Mayo Clinic earlier this week.

From BBC ● Sep. 16, 2026

Hélène Martini, PharmD, PhD, a postdoctoral researcher in the Passos lab at Mayo Clinic, is first author of the publication.

From Science Daily ● Sep. 14, 2026

According to the Mayo Clinic, sea salt is frequently promoted as being healthier, with less sodium than table salt, but in fact they have “the same basic nutritional value.”

From Los Angeles Times ● Sep. 9, 2026

As word has spread, SinoUnited Hospital says it has welcomed patients from MD Anderson, Mayo Clinic and Johns Hopkins Hospital in Baltimore.

From The Wall Street Journal ● Sep. 7, 2026

After leaving the Mayo Clinic, Gey spent several days in New York City at Sloan-Kettering for another study, and he underwent chemotherapy at Hopkins using a drug not yet approved for use in humans.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot