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heavy chain disease

n.
  1. Any of several disorders of lymphocytes characterized by the presence of high-molecular-weight polypeptides, especially gamma-globulins, in serum and urine and by symptoms similar to those of malignant lymphoma.
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.