helicase

American  

[hel-i-keys, hee-li‑] / ˈhɛl ɪˌkeɪs, ˈhi lɪ‑ /

noun

Biochemistry.

1. any of the enzymes that use the energy derived from the hydrolysis of nucleoside triphosphates to unwind the double-stranded helical structure of nucleic acids.

   RNA and DNA helicases.

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Etymology

Origin of helicase

helic- + -ase

Example Sentences

See Examples For:

helicase

These exposed regions attract the BIR machinery, including PIF1, a helicase that is essential for BIR to operate.

From Science Daily ● Dec. 27, 2025

It would be difficult to create safe drugs that target the domains of the enzyme needed for protease or helicase functions, as human cells have many similar molecules.

From Science Daily ● Dec. 8, 2023

If helicase is mutated, the DNA strands will not be joined together at the beginning of replication.

From Textbooks ● Jun. 9, 2022

When an infected cell makes a new piece of the virus’s RNA, for example, a viral protein called a helicase has to unwind it before it can be packaged into a new virus shell.

From New York Times ● Dec. 7, 2021

Cryo-EM structures of the eukaryotic replicative helicase bound to a translocation substrate.

From Nature ● Feb. 27, 2018