IL-2

American  

abbreviation

Immunology, Pharmacology.

1. interleukin 2.

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Example Sentences

For this study, the researchers loaded the patches with a combination of the cytokines IL-2 and CCL-22.

From Science Daily

"By adding a drug that inhibits PGE2 production to the TIL culture medium we restored the ability of TILs to respond to IL-2 and improved the expansion of tumor-reactive TILs more than two-fold," said Grimm.

From Science Daily

The researchers also tracked the growth in culture of 215 individual tumor-reactive TILs that respond to IL-2, which is a key component of TIL cultures, and showed that this is indeed the case.

From Science Daily

Further examination of gene expression data collected from clinical trial samples revealed that TILs that responded poorly to IL-2 expressed relatively large numbers of receptors for PGE2 on their surfaces.

From Science Daily

The resulting loss of IL-2 stimulation initiates a cascade of biochemical events in the cells that culminates in profound metabolic dysfunction, inducing a functional lethargy in the TILs known as "anergy" and ultimately triggering ferroptosis, a type of programmed cell death.

From Science Daily