Dictionary.com
Thesaurus.com

index case

American  
[in-deks keys] / ˈɪn dɛks ˌkeɪs /

noun

Pathology.
  1. the first documented instance of a disease or other medical condition in a population, especially the first infection in an epidemic.

  2. (loosely) index patient.


index case British  

noun

  1. med the first case of a disease, or the primary case referred to in a report

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of index case

First recorded in 1935–40

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

What’s different this time is that the couple who are considered the index case went bird-watching in Chile, Argentina and Uruguay before boarding the cruise ship, according to the World Health Organization.

From MarketWatch May 7, 2026

“There is some evidence that passengers within two rows of an index case are at higher risk,” said Patricia Schlagenhauf, a professor of travel medicine at the University of Zurich.

From Seattle Times Mar. 22, 2022

At least twice, those infections could have spread from an index case to other people, he says.

From Scientific American Feb. 28, 2022

These contacts - people who the "index case" has been in close physical proximity to for long enough to potentially infect them - are then told to isolate and book a test of their own.

From BBC Jul. 1, 2021

G. was the first identified case, the index case, in an outbreak of an unknown virus.

From "The Hot Zone" by Richard Preston

Vocabulary.com logo
by dictionary.com

Dictionary.com's Learning Companion

Go beyond just looking up words.
Remember them forever with VocabTrainer.

Start training