(formerly) extreme depression related to menopause or, less frequently, the male climacteric.
Origin of involutional melancholia
First recorded in 1905–10
Dictionary.com Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019
A form of depression that occurs in late middle age, sometimes accompanied by paranoia.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.