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isoform

American  
[ahy-suh-fawrm] / ˈaɪ səˌfɔrm /

noun

  • isoforms
    plural
  1. Biochemistry. any of the variants of a particular protein, mostly similar to each other in function but having slightly different amino acid sequences.


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Example Sentences

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Notably, an ancestry-biased mRNA isoform of SPSB2, likely driven by cross-population allele frequency differences in rs11064437, was found to be unannotated in canonical gene annotation.

From Science Daily ● Dec. 4, 2024

"We could see if a subset or all set of exons within a gene were differentiated between cancer and normal cells, which allowed us to evaluate cancer-specificity at the isoform versus gene level."

From Science Daily ● May 3, 2024

It turns out that this one chaperone protein had a twin — it’s called an isoform.

From Washington Post ● Sep. 24, 2021

The top and middle panels show isoform sequencing and RNA-seq reads, respectively, that have been mapped to the chromosomal location containing the AUR62017258 gene model, which is shown on the bottom panel.

From Nature ● Feb. 7, 2017

The short deltaN isoform is thought to function as an oncogene, and its expression was most enriched in the classical subtype.

From Nature ● Sep. 26, 2012

This technology allowed the researchers to uncover 214,516 unique isoforms -- over 70% of which have never been previously studied.

From Science Daily ● May 23, 2024

Cancer cells are prone to alternative splicing of exons, which creates isoforms, which the St. Jude analysis detected in a way that had been difficult in earlier screens.

From Science Daily ● May 3, 2024

The researchers found, for example, that for many genes important in neuron-to-neuron signaling, the same cell type expressed different mRNA isoforms in different brain regions.

From Science Daily ● Apr. 9, 2024

This allowed the researchers to identify isoforms from hundreds of thousands of individual mouse and human brain cells.

From Science Daily ● Apr. 9, 2024

Depending on the changes, the cells produce different forms, or isoforms, of proteins.

From Scientific American ● Jun. 8, 2023

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