isoniazid

American  

[ahy-suh-nahy-uh-zid] / ˌaɪ səˈnaɪ ə zɪd /

noun

Pharmacology.

1. a white, crystalline, water-soluble solid, C 6 H 7 N 3 O, used in the treatment of tuberculosis.

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isoniazid British  

/ ˌaɪsəʊˈnaɪəzɪd /

noun

1. a soluble colourless crystalline compound used to treat tuberculosis. Formula: C 6 H 7 N 3 O

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Etymology

Origin of isoniazid

First recorded in 1950–55; short for isonicotinic acid hydrazide

Example Sentences

The biggest worry is extensively drug-resistant TB, known as XDR-TB, which involves resistance to at least four of the core anti-TB drugs, including the two most powerful medicines, isoniazid and rifampicin.

From Scientific American • Aug. 21, 2018

Instead of subjecting them all to a recommended prevention strategy—a 9-month course of the drug isoniazid—they treated half with the 9-month course and half with a monthlong combination of isoniazid and rifapentine.

From Science Magazine • Mar. 5, 2018

Decades later, differences in the metabolism of isoniazid were shown to be caused by inherited variants in the NAT2 gene, which encodes the N-acetyltransferase 2 enzyme11, 12.

From Nature • Oct. 13, 2015

Notably, since 2005, there have been major disruptions in the supply of the TB drug isoniazid, as well as tuberculin, which is used to diagnose TB infection.

From Washington Post

Finally, with the development of such drugs as streptomycin and isoniazid in the 1940s and 1950s, tuberculosis seemed on the way to being vanquished.

From Time Magazine Archive