ligase

American  

[lahy-geys, -geyz] / ˈlaɪ geɪs, -geɪz /

noun

Biochemistry.

1. any of a class of enzymes that catalyze the joining of two molecules by formation of a covalent bond accompanied by the hydrolysis of ATP.

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ligase British  

/ ˈlaɪˌɡeɪz /

noun

1. any of a class of enzymes that catalyse the formation of covalent bonds and are important in the synthesis and repair of biological molecules, such as DNA

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Etymology

Origin of ligase

1961; < Latin lig ( āre ) to tie, bind + -ase

Example Sentences

See Examples For:

ligase

To explore if the elongation of RNA, achieved by linking individual RNA units together, is regulated allosterically, the researchers altered the structure of the R3C ligase.

From Science Daily ● Apr. 18, 2024

This research demonstrated that a network involving HCR3/J3/HSP40 co-chaperone and the chaperone HSP70 controls crossover interference and localization by facilitating the degradation of the pro-crossover protein, HEI10 ubiquitin E3 ligase.

From Science Daily ● Mar. 8, 2024

Beckmann's team has now demonstrated how this substep works: When the translation has finished, the E3 ligase recognizes the large subunit of the ribosomes.

From Science Daily ● Feb. 23, 2024

The gap between the two DNA fragments is sealed by DNA ligase, which helps in the formation of phosphodiester bonds.

From Textbooks ● Jun. 9, 2022

Addition of an enzyme called DNA ligase, which takes part in DNA replication in cells, permanently joins the DNA fragments when the sticky ends come together.

From Textbooks ● Apr. 25, 2013