ligase

American  

[lahy-geys, -geyz] / ˈlaɪ geɪs, -geɪz /

noun

Biochemistry.

1. any of a class of enzymes that catalyze the joining of two molecules by formation of a covalent bond accompanied by the hydrolysis of ATP.

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ligase British  

/ ˈlaɪˌɡeɪz /

noun

1. any of a class of enzymes that catalyse the formation of covalent bonds and are important in the synthesis and repair of biological molecules, such as DNA

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Etymology

Origin of ligase

1961; < Latin lig ( āre ) to tie, bind + -ase

Example Sentences

The team noted that R3C ligase activity was dependent on the concentration of ATP, with higher activity observed at higher concentrations of ATP.

From Science Daily • Apr. 18, 2024

For this, they designed an artificial ribozyme, R3C ligase, to investigate how individual RNA units come together to form a functional structure.

From Science Daily • Apr. 18, 2024

This research demonstrated that a network involving HCR3/J3/HSP40 co-chaperone and the chaperone HSP70 controls crossover interference and localization by facilitating the degradation of the pro-crossover protein, HEI10 ubiquitin E3 ligase.

From Science Daily • Mar. 8, 2024

Once replication is completed, the RNA primers are replaced by DNA nucleotides and the DNA is sealed with DNA ligase.

From Textbooks • Apr. 25, 2013

Addition of an enzyme called DNA ligase, which takes part in DNA replication in cells, permanently joins the DNA fragments when the sticky ends come together.

From Textbooks • Apr. 25, 2013