macromutation

[ mak-roh-myoo-tey-shuhn ]

/ ˌmæk roʊ myuˈteɪ ʃən /

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noun Genetics.

a mutation that has a profound effect on the resulting organism, as a change in a regulatory gene that controls the expression of many structural genes.

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CAN YOU ANSWER THESE COMMON GRAMMAR DEBATES?

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Question 1 of 7

Which sentence is correct?

His boss, whom he admires, is waiting to meet with him about the big project.

His boss, who he admires, is waiting to meet with him about the big project.

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Origin of macromutation

macro- + mutation

How to use macromutation in a sentence

On another, more macro level, did you find Europe to be such a cesspool of intrigue?
How The Cold War Endgame Played Out In The Rubble Of The Berlin Wall|William O’Connor|November 9, 2014|DAILY BEAST
This is the actual Calaveras Fault, forcing its way through town, bringing architectural mutation along with it.
Silicon Valley Mansions, Swallowed Alive|Geoff Manaugh|November 8, 2014|DAILY BEAST
Those with the disease have some cells that are genetically normal and some with the mutation.
The True Story of ‘The Elephant Man’|Russell Saunders|November 3, 2014|DAILY BEAST
Greason started out at Intel but felt the zero-gravity pull of the rocket macro-process in which he now holds 22 patents.
Up to a Point: A 'Space Corvette' in Every Garage|P. J. O’Rourke|September 6, 2014|DAILY BEAST

Yep, organic rice syrup—i.e., sugar—is still its main ingredient, no matter how macro its biotics may be.
Your Health Food’s Hidden Sugar Bomb|Michael Schulson|July 8, 2014|DAILY BEAST
Nor is it difficult to discover some of the circumstances that tended to bring about this radical mutation of policy.
History of the Rise of the Huguenots|Henry Baird
Do species change by the gradual elimination of the unfit, or do they change by sudden leaps, the "mutation" theory of de Vries?
The Book of Life: Vol. I Mind and Body; Vol. II Love and Society|Upton Sinclair
There is no trace of such vocalic mutation (“umlaut”) in Gothic, our most archaic Germanic language.
Language|Edward Sapir
Still more remarkable is the mutation and addition of new words of especially definite meaning among certain classes.
Criminal Psychology|Hans Gross
Such differentiations in tone our own people make also, and the mutation of meaning is very close.
Criminal Psychology|Hans Gross