macromutation

[ mak-roh-myoo-tey-shuhn ]

/ ˌmæk roʊ myuˈteɪ ʃən /

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noun Genetics.

a mutation that has a profound effect on the resulting organism, as a change in a regulatory gene that controls the expression of many structural genes.

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Origin of macromutation

macro- + mutation

How to use macromutation in a sentence

On another, more macro level, did you find Europe to be such a cesspool of intrigue?
How The Cold War Endgame Played Out In The Rubble Of The Berlin Wall|William O’Connor|November 9, 2014|DAILY BEAST
This is the actual Calaveras Fault, forcing its way through town, bringing architectural mutation along with it.
Silicon Valley Mansions, Swallowed Alive|Geoff Manaugh|November 8, 2014|DAILY BEAST
Those with the disease have some cells that are genetically normal and some with the mutation.
The True Story of ‘The Elephant Man’|Russell Saunders|November 3, 2014|DAILY BEAST
Greason started out at Intel but felt the zero-gravity pull of the rocket macro-process in which he now holds 22 patents.
Up to a Point: A 'Space Corvette' in Every Garage|P. J. O’Rourke|September 6, 2014|DAILY BEAST

Yep, organic rice syrup—i.e., sugar—is still its main ingredient, no matter how macro its biotics may be.
Your Health Food’s Hidden Sugar Bomb|Michael Schulson|July 8, 2014|DAILY BEAST
Nor is it difficult to discover some of the circumstances that tended to bring about this radical mutation of policy.
History of the Rise of the Huguenots|Henry Baird
Do species change by the gradual elimination of the unfit, or do they change by sudden leaps, the "mutation" theory of de Vries?
The Book of Life: Vol. I Mind and Body; Vol. II Love and Society|Upton Sinclair
There is no trace of such vocalic mutation (“umlaut”) in Gothic, our most archaic Germanic language.
Language|Edward Sapir
Still more remarkable is the mutation and addition of new words of especially definite meaning among certain classes.
Criminal Psychology|Hans Gross
Such differentiations in tone our own people make also, and the mutation of meaning is very close.
Criminal Psychology|Hans Gross