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macromutation

American  
[mak-roh-myoo-tey-shuhn] / ˌmæk roʊ myuˈteɪ ʃən /

noun

Genetics.
  1. a mutation that has a profound effect on the resulting organism, as a change in a regulatory gene that controls the expression of many structural genes.


Etymology

Origin of macromutation

macro- + mutation

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