macrophage

American  

[mak-ruh-fayj] / ˈmæk rəˌfeɪdʒ /

noun

Cell Biology.

1. a large white blood cell, occurring principally in connective tissue and in the bloodstream, that ingests foreign particles and infectious microorganisms by phagocytosis.

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macrophage British  

/ ˈmækrəʊˌfeɪdʒ /

noun

1. any large phagocytic cell occurring in the blood, lymph, and connective tissue of vertebrates See also histiocyte

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macrophage Scientific  

/ măk′rə-fāj′ /

1. Any of various large white blood cells that play an essential immunologic role in vertebrates and some lower organisms by eliminating cellular debris and particulate antigens, including bacteria, through phagocytosis. Macrophages develop from circulating monocytes that migrate from the blood into tissues throughout the body, especially the spleen, liver, lymph nodes, lungs, brain, and connective tissue. Macrophages also participate in the immune response by producing and responding to inflammatory cytokines.

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Other Word Forms

• macrophagic
  adjective

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Etymology

Origin of macrophage

From the New Latin word macrophagus, dating back to 1885–90. See macro-, -phage

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Example Sentences

See Examples For:

macrophage

Approaches that influence macrophage polarization are especially promising, with several drugs showing an ability to encourage M2 states and speed wound closure.

From Science Daily ● Oct. 10, 2026

They found that the same senescent macrophage signature was significantly higher in diseased livers than in healthy ones.

From Science Daily ● Apr. 16, 2026

"This occurs in a very rapid fashion. You can activate the macrophage and make the muscle twitch subtly almost immediately," Jankowski says.

From Science Daily ● Nov. 24, 2025

This runaway inflammation is a hallmark of many diseases, making macrophage regulation a key target for improving recovery and reducing chronic conditions.

From Science Daily ● Oct. 30, 2025

The other form of amoeboid cell, which Metschnikoff calls the macrophage, has more feeble phagocytic action towards bacteria, and these are rarely found enclosed within them.

From Disease and Its Causes by William Thomas Councilman

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