Showing results for major depressive disorder. Search instead for depressive+disorder.

major depressive disorder

American

[may-jer-di-pres-iv-dis-awr-der] / ˈmeɪ dʒər dɪˈprɛs ɪv dɪsˈɔr dər /

noun

Psychiatry. an affective disorder characterized by a sustained period of low mood, diminished self-esteem, and reduced interest in normally enjoyable activities.

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

The biopharmaceutical company’s drug, BHV-7000, failed to meet its primary endpoint for the treatment of major depressive disorder in a phase 2 trial, the company said on Wednesday.

From Barron's • Dec. 26, 2025

Antidepressants are typically prescribed for people with major depressive disorder.

From The Wall Street Journal • Nov. 11, 2025

A group of 82 participants with major depressive disorder was assessed using two innovative methods.

From Science Daily • Nov. 25, 2024

Behind its glassy doors is something rare: A community run by people with serious mental health conditions such as schizophrenia, bipolar disorder and major depressive disorder.

From Los Angeles Times • Nov. 2, 2024

At one point, Crooks searched "major depressive disorder" on one of his cellphones.

From Salon • Jul. 18, 2024

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023