mandibuloacral dysplasia

[măn-dĭb′yə-lō-ăkrəl]
n.
  1. A hereditary disorder characterized by dental crowding, ulceration and wasting of the skin on the hands and feet, softening and destruction of the bones, and stiff joints.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.