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• mayo
  mayo

  noun

  mayonnaise.
• Mayo
  Mayo

  noun

  Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

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Slang dictionary results for mayo.

mayo

¹ American  

[may-oh] / ˈmeɪ oʊ /

noun

Informal.

1. mayonnaise.

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Mayo ² American  

[may-oh] / ˈmeɪ oʊ /

noun

1. Charles Horace, 1865–1939, and his brother William James, 1861–1939, U.S. surgeons.

2. a county in NW Connaught province, in the NW Republic of Ireland. 2,084 sq. mi. (5,400 sq. km). Castlebar.

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Mayo ¹ British  

/ ˈmeɪəʊ /

noun

1. a county of NW Republic of Ireland, in NW Connacht province, on the Atlantic: has many offshore islands and several large lakes. County town: Castlebar. Pop: 117 446 (2002). Area: 5397 sq km (2084 sq miles)

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Mayo ² British  

/ ˈmeɪəʊ /

noun

1. a family of US medical practitioners. They pioneered group practice and established (1903) the Mayo Clinic in Rochester, Minnesota. Foremost among them were William Worrall Mayo (1819–1911), his sons William James Mayo (1861–1939) and Charles Horace Mayo (1865–1939), and Charles's son, Charles William Mayo (1898–1968)

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Usage

What else does mayo mean? Typically, mayo is short for mayonnaise, a classic condiment made of oil, vinegar, and egg yolks. When not, it can also be used as offensive language against white people or a slang term for drugs. Content warning: the following article deals with content related to illicit drugs and offensive and disparaging language.

Etymology

Origin of mayo

By shortening; cf. -o

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Example Sentences

See Examples For:

mayo Mayo

Unlike bleach and wipes, a product made of buttermilk and mayo is not exactly designed for mass consumption.

From The Wall Street Journal ● Jul. 17, 2026

It has a gloss to it, a kind of quiet sheen that standard mayo simply does not.

From Salon ● Apr. 14, 2026

Chia seeds are a nutrient-dense replacement for eggs, meaning you can make plant-based cookies and even plant-based mayo.

From Salon ● Mar. 31, 2026

I made a mayo line because: there’s such a delta between a sandwich made in the average American home and one made in great sandwich shops.

From The Wall Street Journal ● Feb. 11, 2026

She slid a plate of pepper-flecked fried eggs onto the table and set the mayo beside it.

From "We Are the Ants" by Shaun David Hutchinson

“An annuity advertised as having no fees can still pay a commission to the adviser who sells it,” said James Mayo, a certified financial planner and principal of IronFjord Wealth Management.

From MarketWatch ● Nov. 6, 2026

It is believed the pair are originally from overseas but live in Ireland and were on a visit to Achill Island, off the County Mayo coast, when the incident happened.

From BBC ● Oct. 30, 2026

Arteriosclerosis occurs when blood vessels carrying oxygen and nutrients from the heart to the body become thick and stiff, according to the Mayo Clinic.

From Los Angeles Times ● Oct. 30, 2026

Bonta alleges in the lawsuit that defendants have “repeatedly, consistently, and pervasively failed to lawfully manage hazardous waste” at the landfill located on Henry Mayo Drive.

From Los Angeles Times ● Oct. 29, 2026

After leaving the Mayo Clinic, Gey spent several days in New York City at Sloan-Kettering for another study, and he underwent chemotherapy at Hopkins using a drug not yet approved for use in humans.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot

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