MHC

American  

1. major histocompatibility complex: (in mammals) a group of genes located next to or near each other on a specific chromosome, the sixth in humans, most of which encode glycoproteins of highly variable shapes that are expressed on almost all cell surfaces: it plays the dominant role in distinguishing one individual's cells from another's and in determining the histocompatibility of any two individuals.

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MHC British  

abbreviation

1. major histocompatibility complex; a series of genes located on chromosome 6 that code for antigens. They are important in determining histocompatibility

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Example Sentences

See Examples For:

MHC

When MHC I levels were reduced, cancer cells became more susceptible to attacks from CD4+ T cells.

From Science Daily ● Jun. 4, 2026

For decades, scientists believed that MHC class I molecules primarily communicated with CD8+ T cells, often called "killer" T cells, while MHC class II molecules activated CD4+ T cells, commonly known as "helper" T cells.

From Science Daily ● Jun. 4, 2026

This accumulation of succinate led to expression of immune genes in the nucleus and increased the levels of a protein called MHC on the surface of the tumor.

From Science Daily ● Sep. 21, 2023

MHC class II molecules are found on cells that present antigens.

From Textbooks ● Jan. 1, 2015

These proteins combine with MHC class I molecules that move to the outer cell membrane for display.

From Textbooks ● Jan. 1, 2015

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