MHC

American  

1. major histocompatibility complex: (in mammals) a group of genes located next to or near each other on a specific chromosome, the sixth in humans, most of which encode glycoproteins of highly variable shapes that are expressed on almost all cell surfaces: it plays the dominant role in distinguishing one individual's cells from another's and in determining the histocompatibility of any two individuals.

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MHC British  

abbreviation

1. major histocompatibility complex; a series of genes located on chromosome 6 that code for antigens. They are important in determining histocompatibility

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Example Sentences

See Examples For:

MHC

The results indicate that lowering MHC I expression can increase the ability of CD4+ T cells to destroy target cells, whether those cells are cancerous or allogeneic.

From Science Daily ● Jun. 4, 2026

The researchers identified a previously unrecognized role for the MHC class I pathway in immune responses driven by CD4+ T cells, challenging the traditional view that these pathways operate separately.

From Science Daily ● Jun. 4, 2026

Using advanced transcriptomic analyses and functional studies in both mouse models and human samples, the researchers examined what happens when cancer cells lose MHC I expression.

From Science Daily ● Jun. 4, 2026

MHC molecules reside on cell membranes and contain a variable region.

From Textbooks ● Jan. 1, 2015

These proteins combine with MHC class I molecules that move to the outer cell membrane for display.

From Textbooks ● Jan. 1, 2015