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minimal lethal dose

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n.
The smallest quantity of a toxic substance or infectious agent that is found to be lethal.
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The rainy weather could not ________ my elated spirits on my graduation day.
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

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