misfold
Americanverb (used without object)
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
See Examples For:
When proteins inside the eye misfold, cells can respond in several ways.
From Science Daily ● Nov. 8, 2025
CJD is the most prominent of the handful of diseases, all fatal, that result when prions, proteins of uncertain function that are abundant in the brain, misfold into an infective form that spreads widely.
From Science Magazine ● Mar. 21, 2024
The research suggests that SARS-CoV-2 can cause normal proteins to abnormally misfold.
From Salon ● Apr. 24, 2023
A mutation in the gene that provides instructions for producing the transthyretin protein causes it to misfold and deposit in the body’s tissue and organs, disrupting normal function.
From Washington Post ● Feb. 5, 2022
We do not know precisely how all of these proteins fold correctly, much less what goes wrong when they misfold.
From Scientific American ● Jun. 22, 2021
The investigators also identified additional partner proteins involved in folding and transporting proinsulin, as well as detecting and managing misfolded versions.
From Science Daily ● Jul. 28, 2026
They genetically engineered mice so that either mGluR4 or NPDC1 no longer functioned, then exposed the animals to misfolded α-synuclein.
From Science Daily ● Jul. 12, 2026
A key feature of the disease is the buildup of a misfolded protein called α-synuclein.
From Science Daily ● Jul. 12, 2026
It looked at 17 studies, involving 20,342 volunteers, of drugs that remove amyloid - a misfolded protein present in disease - from the brain.
From BBC ● May 22, 2026
When tau becomes misfolded, it starts clumping together into long, fibrous aggregates known as fibrils.
From Science Daily ● Nov. 15, 2025
This underscores the need for investigating compounds and strategies that can suppress misfolding and enhance protein stabilization.
From Science Daily ● May 30, 2024
Still other groups are seeking to develop small molecules or antibodies that act later in the process, preventing prion protein from misfolding or limiting the damage of the pernicious form.
From Science Magazine ● Mar. 21, 2024
"The assumption used to be that every neurodegenerative disease was characterized by the misfolding of a specific protein," explains Jörg Tatzelt.
From Science Daily ● Dec. 4, 2023
In the context of prolonging our health, this means that nature will have discovered many ways of combating the inherently destructive processes of life, such as free-radical damage and protein misfolding.
From Salon ● Aug. 20, 2022
Diminished expression of heat-shock protein genes in humans could raise the risk of illnesses, such as Alzheimer’s disease, in which the misfolding of proteins is implicated, the researchers report in their paper.
From Scientific American ● Mar. 22, 2022
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
