misfold
Americanverb (used without object)
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
See Examples For:
When proteins inside the eye misfold, cells can respond in several ways.
From Science Daily ● Nov. 8, 2025
CJD is the most prominent of the handful of diseases, all fatal, that result when prions, proteins of uncertain function that are abundant in the brain, misfold into an infective form that spreads widely.
From Science Magazine ● Mar. 21, 2024
Change just one amino acid in the hundreds of amino acids typically found in a protein and it may misfold and no longer work.
From Salon ● Jun. 20, 2022
A mutation in the gene that provides instructions for producing the transthyretin protein causes it to misfold and deposit in the body’s tissue and organs, disrupting normal function.
From Washington Post ● Feb. 5, 2022
We do not know precisely how all of these proteins fold correctly, much less what goes wrong when they misfold.
From Scientific American ● Jun. 22, 2021
These problems develop as misfolded α-synuclein accumulates in motor neurons.
From Science Daily ● Jul. 12, 2026
A new study published in Nature Communications points to two membrane proteins, mGluR4 and NPDC1, as critical transporters that help carry the misfolded protein into healthy brain cells.
From Science Daily ● Jul. 12, 2026
A key feature of the disease is the buildup of a misfolded protein called α-synuclein.
From Science Daily ● Jul. 12, 2026
It looked at 17 studies, involving 20,342 volunteers, of drugs that remove amyloid - a misfolded protein present in disease - from the brain.
From BBC ● May 22, 2026
"Ketone bodies interact with damaged and misfolded proteins directly, making them insoluble so they can be pulled from the cell and recycled."
From Science Daily ● Dec. 2, 2024
This underscores the need for investigating compounds and strategies that can suppress misfolding and enhance protein stabilization.
From Science Daily ● May 30, 2024
The response prevents proteins in the recipient tissues from misfolding.
From Science Magazine ● May 22, 2024
Abacavir exposure triggered HLA misfolding in the ER, leading to ER stress.
From Science Daily ● May 15, 2024
In the context of prolonging our health, this means that nature will have discovered many ways of combating the inherently destructive processes of life, such as free-radical damage and protein misfolding.
From Salon ● Aug. 20, 2022
Diminished expression of heat-shock protein genes in humans could raise the risk of illnesses, such as Alzheimer’s disease, in which the misfolding of proteins is implicated, the researchers report in their paper.
From Scientific American ● Mar. 22, 2022
Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023
Idioms from The American Heritage® Idioms Dictionary copyright © 2002, 2001, 1995 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company.
