misfold
Americanverb (used without object)
Example Sentences
Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.
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"Free oxygen radicals damage proteins, which causes them to misfold and aggregate, then fatty protein deposits called drusen begin to accumulate, which is the main diagnostic criterion for the dry form of age-related macular degeneration."
From Science Daily ● Nov. 8, 2025
CJD is the most prominent of the handful of diseases, all fatal, that result when prions, proteins of uncertain function that are abundant in the brain, misfold into an infective form that spreads widely.
From Science Magazine ● Mar. 21, 2024
The research suggests that SARS-CoV-2 can cause normal proteins to abnormally misfold.
From Salon ● Apr. 24, 2023
A mutation in the gene that provides instructions for producing the transthyretin protein causes it to misfold and deposit in the body’s tissue and organs, disrupting normal function.
From Washington Post ● Feb. 5, 2022
We do not know precisely how all of these proteins fold correctly, much less what goes wrong when they misfold.
From Scientific American ● Jun. 22, 2021
The E3 ligase enzyme cleans up the cell, tagging proteins that are damaged or misfolded for destruction.
From The Wall Street Journal ● Oct. 15, 2026
A key feature of the disease is the buildup of a misfolded protein called α-synuclein.
From Science Daily ● Jul. 12, 2026
They genetically engineered mice so that either mGluR4 or NPDC1 no longer functioned, then exposed the animals to misfolded α-synuclein.
From Science Daily ● Jul. 12, 2026
It looked at 17 studies, involving 20,342 volunteers, of drugs that remove amyloid - a misfolded protein present in disease - from the brain.
From BBC ● May 22, 2026
Under normal conditions, SEL1L acts as part of the cell's quality control system by identifying damaged or misfolded proteins and marking them for destruction.
From Science Daily ● May 21, 2026
"Our findings open up new possibilities for developing arginine-based strategies for neurodegenerative diseases caused by protein misfolding and aggregation," notes Prof. Nagai.
From Science Daily ● Nov. 21, 2025
Protein misfolding has been implicated as the underlying cause of a range of human diseases, notably Alzheimer's, Huntington's, and Parkinson's.
From Science Daily ● May 30, 2024
Still other groups are seeking to develop small molecules or antibodies that act later in the process, preventing prion protein from misfolding or limiting the damage of the pernicious form.
From Science Magazine ● Mar. 21, 2024
In the context of prolonging our health, this means that nature will have discovered many ways of combating the inherently destructive processes of life, such as free-radical damage and protein misfolding.
From Salon ● Aug. 20, 2022
Diminished expression of heat-shock protein genes in humans could raise the risk of illnesses, such as Alzheimer’s disease, in which the misfolding of proteins is implicated, the researchers report in their paper.
From Scientific American ● Mar. 22, 2022
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