missense

American  

[mis-sens] / ˈmɪsˌsɛns /

adjective

1. Genetics. relating to or being a genetic mutation involving a nucleotide change that alters a codon and results in the substitution of one amino acid for another in the protein.

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missense Scientific  

/ mĭs′sĕns′ /

1. Relating to a mutation that changes a codon for one amino acid into a codon for a different amino acid.

2. See more at point mutation

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Example Sentences

The team then created transgenic flies with the four missense variants found in affected individuals using two different genetic methods.

From Science Daily • Mar. 14, 2024

Among the cohort, 46 patients had missense variants of the gene U2AF2 and six patients had variants of the gene PRPF19.

From Science Daily • Nov. 28, 2023

The researchers also used AlphaMissense to create a catalogue of every possible missense mutation in the human genome, determining that 57% are likely to be benign and that 32% may cause disease.

From Scientific American • Sep. 21, 2023

Mutations that change the amino acid specified by a codon can be more significant and are called missense mutations.

From Textbooks • Jan. 1, 2018

In total, two frameshift, two nonsense and one missense mutation, combined with a homozygous deletion spanning the coding region were observed.

From Nature • Jun. 20, 2012