missense

American  

[mis-sens] / ˈmɪsˌsɛns /

adjective

1. Genetics. relating to or being a genetic mutation involving a nucleotide change that alters a codon and results in the substitution of one amino acid for another in the protein.

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missense Scientific  

/ mĭs′sĕns′ /

1. Relating to a mutation that changes a codon for one amino acid into a codon for a different amino acid.

2. See more at point mutation

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Example Sentences

The team then created transgenic flies with the four missense variants found in affected individuals using two different genetic methods.

From Science Daily • Mar. 14, 2024

Deeper profiling revealed that at third gene, RBFOX1, had missense variants that affected splicing and loss of proper neuron function.

From Science Daily • Nov. 28, 2023

So when researchers and doctors find a missense mutation they’ve never seen before, it can be difficult to know what to make of it.

From Scientific American • Sep. 21, 2023

Mutations that change the amino acid specified by a codon can be more significant and are called missense mutations.

From Textbooks • Jan. 1, 2018

And there are few ways to assess predictive algorithms, particularly those that go beyond evaluating missense mutations, says John Moult, a bioinformatician at the University of Maryland in Rockville.

From Nature • Feb. 8, 2012