neurofibromatosis

American  

[noor-oh-fahy-broh-muh-toh-sis, nyoor-] / ˌnʊər oʊ faɪˌbroʊ məˈtoʊ sɪs, ˌnyʊər- /

noun

Pathology.

1. a dominantly inherited genetic disorder characterized by flat brown patches on the skin, neurofibromas of the skin and internal organs, and in some cases skeletal deformity.

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neurofibromatosis British  

/ ˌnjʊərəʊˌfaɪbrəməˈtəʊsɪs /

noun

1. a condition characterized by the formation of benign tumours on the fibrous coverings of the peripheral nerves and the development of areas of café-au-lait spots

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neurofibromatosis Scientific  

/ nr′ō-fī′brō-mə-tō′sĭs /

1. A genetic disease characterized by multiple benign tumors of peripheral nerves, called neurofibromas, and pigmented spots on the skin, sometimes accompanied by bone deformity and a predisposition to cancers, especially of the brain.

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Etymology

Origin of neurofibromatosis

1895–1900; < New Latin neurofibromat-, stem of neurofibroma neurofibroma + -osis

Example Sentences

In his speech, Stan first thanked his costar Adam Pearson, who has neurofibromatosis and on whom the film’s director, Aaron Schimberg, based Stan’s character’s look.

From Salon • Jan. 6, 2025

Dean Stalham's daughter, Bunty, was born with a rare bone disease called neurofibromatosis.

From BBC • Dec. 5, 2024

Directed by Aaron Schimberg, the film stars Stan as an actor with neurofibromatosis who undergoes an experimental surgery to remove tumors from his face, giving him a more conventional appearance.

From New York Times • Dec. 3, 2024

Department of Defense in 2006 to find therapies for all forms of neurofibromatosis.

From Science Daily • Apr. 15, 2024

Sebastian Stan plays Edward, an actor with the genetic condition known as neurofibromatosis, visualized here by large, fleshy facial prosthetics.

From Los Angeles Times • Jan. 26, 2024