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Showing results for psychoactive. Search instead for nonpsychoactive.
Synonyms

psychoactive

American  
[sahy-koh-ak-tiv] / ˌsaɪ koʊˈæk tɪv /

adjective

  1. of or relating to a substance having a profound or significant effect on mental processes.

    a psychoactive drug.


psychoactive British  
/ ˌsaɪkəʊˈæktɪv /

adjective

  1. capable of affecting mental activity

    a psychoactive drug

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of psychoactive

First recorded in 1960–65; psycho- + active

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Vocabulary lists containing psychoactive

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

"Caffeine is the most widely consumed psychoactive substance in the world, with about 85% of adults in the U.S. using it regularly," said Sabandal, research assistant professor in UTEP's Department of Biological Sciences.

From Science Daily • Mar. 31, 2026

But the mushrooms used in coffees, like lion's mane, are a different species to magic mushrooms and aren't psychoactive.

From BBC • Nov. 22, 2025

McConnell, who championed hemp back in 2018, has since argued in favor of closing what he has called a loophole that allows psychoactive products to be marketed as legal alternatives to marijuana.

From The Wall Street Journal • Nov. 12, 2025

Ibogaine is a psychoactive compound from the root bark of a West African shrub and has been used by Indigenous people for medical and spiritual purposes for hundreds of years.

From Los Angeles Times • Jun. 26, 2025

Companies are also starting forays into other mushrooms that aren’t psychoactive but have other reported cognitive effects.

From Slate • Jul. 18, 2024

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