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nuclease

American  
[noo-klee-eys, -eyz, nyoo-] / ˈnu kliˌeɪs, -ˌeɪz, ˈnyu- /

noun

Biochemistry.
  1. any enzyme that catalyzes the hydrolysis of nucleic acids.


nuclease British  
/ ˈnjuːklɪˌeɪz /

noun

  1. any of a group of enzymes that hydrolyse nucleic acids to simple nucleotides

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of nuclease

1900–05; nucle(ic acid) ( def. ) + -ase

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

"We now want to address this huge, fundamental biological question -- how does complex assembly switch SIR2's activity from a nuclease to an NADase?"

From Science Daily • Dec. 13, 2023

But soon after fertilization, the nuclease cuts the DNA sequence on the other chromosome from the parent that did not carry the gene at the precise location of the gene drive.

From Scientific American • Jan. 13, 2023

It took Dr. Bao’s lab more than two years of development, and then zinc finger nuclease would successfully cut the sickle cell sequence only around 10 percent of the time.

From New York Times • Jun. 27, 2022

The nuclease produces a double-strand break, which is repaired using the host cell’s machinery.

From Nature • Jun. 11, 2019

Two types of pancreatic nuclease are responsible for their digestion: deoxyribonuclease, which digests DNA, and ribonuclease, which digests RNA.

From Textbooks • Jun. 19, 2013

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