oligonucleotide

[ol-i-goh-noo-klee-uh-tahyd, -nyoo-]

noun

Biochemistry.

1. a chain of a few nucleotides.

oligonucleotide

/ ˌɒlɪɡəʊˈnjuːklɪəˌtaɪd /

noun

1. a polymer consisting of a small number of nucleotides

Word History and Origins

Origin of oligonucleotide¹

First recorded in 1940–45; oligo- + nucleotide

Example Sentences

Through the acquisition, Novartis is also gaining access to a new class of RNA therapeutics, called antibody oligonucleotide conjugate, with a platform that enables delivering RNA therapy to muscle, UBS says.

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Avidity is developing gene-based drugs that use an emerging technology known as antibody oligonucleotide conjugates to deliver RNA treatment to muscles.

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Similarly, a different antisense oligonucleotide linked to BCC10 greatly reduced another gene, Mapt, which encodes the tau protein and is a target for the treatment of Alzheimer's disease and other dementias.

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The announcement came a week after drugmakers Biogen and Ionis Pharmaceuticals said they are terminating development of BIIB105, an antisense oligonucleotide for ALS that showed disappointing results in an early-stage clinical study.

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The noteworthy aspect of this method is the elimination of the need for specialized and expensive ON building blocks to integrate peptides into the oligonucleotide sequence.

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