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oligonucleotide

American  
[ol-i-goh-noo-klee-uh-tahyd, -nyoo-] / ˌɒl ɪ goʊˈnu kli əˌtaɪd, -ˈnyu- /

noun

Biochemistry.
  1. a chain of a few nucleotides.


oligonucleotide British  
/ ˌɒlɪɡəʊˈnjuːklɪəˌtaɪd /

noun

  1. a polymer consisting of a small number of nucleotides

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of oligonucleotide

First recorded in 1940–45; oligo- + nucleotide

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Avidity is developing gene-based drugs that use an emerging technology known as antibody oligonucleotide conjugates to deliver RNA treatment to muscles.

From The Wall Street Journal • Oct. 26, 2025

Similarly, a different antisense oligonucleotide linked to BCC10 greatly reduced another gene, Mapt, which encodes the tau protein and is a target for the treatment of Alzheimer's disease and other dementias.

From Science Daily • Nov. 25, 2024

The announcement came a week after drugmakers Biogen and Ionis Pharmaceuticals said they are terminating development of BIIB105, an antisense oligonucleotide for ALS that showed disappointing results in an early-stage clinical study.

From Science Magazine • May 22, 2024

Ionis’s drug, called an antisense oligonucleotide, is a snippet of single-stranded DNA.

From Scientific American • Jan. 16, 2018

Then, copying an oligonucleotide of just 20 base pairs took a chemist two years.

From Nature • May 18, 2011