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oligonucleotide

American  
[ol-i-goh-noo-klee-uh-tahyd, -nyoo-] / ˌɒl ɪ goʊˈnu kli əˌtaɪd, -ˈnju- /

noun

Biochemistry.
  1. a chain of a few nucleotides.


oligonucleotide British  
/ ˌɒlɪɡəʊˈnjuːklɪəˌtaɪd /

noun

  1. a polymer consisting of a small number of nucleotides

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of oligonucleotide

First recorded in 1940–45; oligo- + nucleotide

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

See Examples For:

Through the acquisition, Novartis is also gaining access to a new class of RNA therapeutics, called antibody oligonucleotide conjugate, with a platform that enables delivering RNA therapy to muscle, UBS says.

From The Wall Street Journal Oct. 27, 2025

The announcement came a week after drugmakers Biogen and Ionis Pharmaceuticals said they are terminating development of BIIB105, an antisense oligonucleotide for ALS that showed disappointing results in an early-stage clinical study.

From Science Magazine May 22, 2024

The noteworthy aspect of this method is the elimination of the need for specialized and expensive ON building blocks to integrate peptides into the oligonucleotide sequence.

From Science Daily Dec. 13, 2023

Another genetic approach that is a bit gray around the categorical edges is known as oligonucleotide therapy.

From Scientific American Oct. 19, 2021

Even if oligonucleotide strands could make it to a cell that contained the target mRNA, that cell has an outer membrane that acts as a barrier to prevent the oligonucleotides from getting inside.

From Nature Dec. 3, 2019

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