oligonucleotide

American  

[ol-i-goh-noo-klee-uh-tahyd, -nyoo-] / ˌɒl ɪ goʊˈnu kli əˌtaɪd, -ˈnyu- /

noun

Biochemistry.

1. a chain of a few nucleotides.

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oligonucleotide British  

/ ˌɒlɪɡəʊˈnjuːklɪəˌtaɪd /

noun

1. a polymer consisting of a small number of nucleotides

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Etymology

Origin of oligonucleotide

First recorded in 1940–45; oligo- + nucleotide

Example Sentences

"Although morpholinos themselves are not an option because of their toxicity, similar strategies, like antisense oligonucleotide therapies already used in other conditions, could potentially be developed for Rett syndrome."

From Science Daily

Through the acquisition, Novartis is also gaining access to a new class of RNA therapeutics, called antibody oligonucleotide conjugate, with a platform that enables delivering RNA therapy to muscle, UBS says.

From The Wall Street Journal

Avidity is developing gene-based drugs that use an emerging technology known as antibody oligonucleotide conjugates to deliver RNA treatment to muscles.

From The Wall Street Journal

Similarly, a different antisense oligonucleotide linked to BCC10 greatly reduced another gene, Mapt, which encodes the tau protein and is a target for the treatment of Alzheimer's disease and other dementias.

From Science Daily

The announcement came a week after drugmakers Biogen and Ionis Pharmaceuticals said they are terminating development of BIIB105, an antisense oligonucleotide for ALS that showed disappointing results in an early-stage clinical study.

From Science Magazine