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progressive systemic sclerosis

n.
  1. A systemic disease marked by formation of hyalinized and thickened collagenous fibrous tissue, with thickening and adhesion of skin to underlying tissues, especially of the hands and face.scleroderma
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.