[ proh-tuh-meen, pro-tam-in ]
/ ˈproʊ təˌmin, prɒˈtæm ɪn /

noun Biochemistry.

any of a group of arginine-rich, strongly basic proteins that are not coagulated by heat, occurring primarily in the sperm of fish.

Origin of protamine

First recorded in 1870–75; prot- + amine Unabridged Based on the Random House Unabridged Dictionary, © Random House, Inc. 2019

British Dictionary definitions for protamine


/ (ˈprəʊtəˌmiːn) /


any of a group of basic simple proteins that occur, in association with nucleic acids, in the sperm of some fish

Word Origin for protamine

C19: from German: see proto-, amine
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Medicine definitions for protamine


[ prōtə-mēn′, -mĭn ]


Any of a group of simple proteins found in fish sperm that are strongly basic, are soluble in water, are not coagulated by heat, and yield chiefly arginine upon hydrolysis. In purified form, they are used in a long-acting formulation of insulin and to neutralize the anticoagulant effects of heparin.
The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.