PSA

American  

abbreviation

1. prostate specific antigen: a protein, produced by the prostate, elevated levels of which may indicate the presence of cancer.

2. public service announcement: an audio or video spot or advertisement to educate or promote awareness about health, safety, civics, etc.

3. positive security assurance.

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PSA British  

abbreviation

1. prostatic specific antigen: an enzyme secreted by the prostate gland, increased levels of which are found in the blood of patients with cancer of the prostate

2. (in New Zealand) Public Service Association

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PSA Scientific  

1. Abbreviation of prostatic-specific antigen

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Example Sentences

Here’s a PSA if you’re flying Sunday: Don’t forget to change your clocks when you go to bed on Saturday.

From The Wall Street Journal • Mar. 6, 2026

In a Phase 1 trial, 14 of 17 patients showed at least a 50% reduction in prostate-specific antigen, or PSA, a protein that indicates the presence of prostate cancer at elevated levels.

From Barron's • Feb. 24, 2026

Paul’s card was graded 10 by Professional Sports Authenticators, or PSA, a third-party service that authenticates and grades trading cards and other collectibles.

From Los Angeles Times • Feb. 17, 2026

After nine days in the capital, they returned to Savannah on a large Airbus jet carrying Sam’s casket, accompanied by more than a dozen PSA pilots.

From The Wall Street Journal • Feb. 14, 2026

The same meme makes the rounds every storm: “Tornado season PSA: Bras on, teeth in!”

From "Legendary Frybread Drive-In" by Cynthia Leitich Smith