spermidine

American  

[spur-mi-deen, -din] / ˈspɜr mɪˌdin, -dɪn /

noun

Biochemistry.

1. a biogenic polyamine, H 2 N(CH2 ) 4 NH(CH2 ) 3 NH 2 , formed from putrescine, occurring widely in nature and first identified in semen.

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Etymology

Origin of spermidine

First recorded in 1925–30; sperm- + -idine

Example Sentences

They first reduced polyamine levels using a drug, then restored them by adding spermidine.

From Science Daily • Mar. 2, 2026

In recent years, scientists have focused on these compounds, especially spermidine, for their potential to support healthy aging.

From Science Daily • Mar. 2, 2026

They determined that lubiprostone boosts the production of spermidine, a compound that enhances mitochondrial activity by encouraging the growth of beneficial gut bacteria.

From Science Daily • Dec. 3, 2025

One possible way to explain this is if the core apoptotic machinery prevents ornithine from entering the mitochondrion and instead diverts it towards spermidine production.

From Nature • Mar. 17, 2020

How do spermidine, guanosine monophosphate and inosine monophosphate induce responses in macrophages, and why do the three metabolites work only when given together?

From Nature • Mar. 17, 2020