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spongy degeneration

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n.
A rare, inherited, fatal brain disease of infancy characterized by the widespread loss of myelin from nerve sheaths and the presence of round empty spaces in the brain, giving it a spongelike appearance, and resulting in progressive paralysis, blindness, and megalencephaly.Canavan's disease
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.

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