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stop codon

American  

noun

Genetics.
  1. a codon that stops the synthesis of a protein molecule.


stop codon Scientific  
/ stŏp /
  1. Any of three codons in a molecule of messenger RNA that do not code for an amino acid and thereby signal the termination of the synthesis of a protein. The three stop codons are UAA, UAG, and UGA, where U is uracil, A is adenine, and G is guanine.

  2. Also called termination codon


Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Researchers had assumed that these organisms simply reassigned the UAG stop codon to represent pyrrolysine.

From Science Daily • Feb. 28, 2026

It treats a particular three letter sequence, typically a stop codon that marks the end of a protein, in two different ways.

From Science Daily • Feb. 28, 2026

They swapped out the same stop codon in E. coli, but they added another layer of protection.

From Science Magazine • Oct. 19, 2022

There is a silent mutation in peptide 3 and peptide 2 has a stop codon due to mutation.

From Textbooks • Jun. 9, 2022

When a stop codon is encountered, a release factor binds and dissociates the components and frees the new protein.

From Textbooks • Apr. 25, 2013