substantia nigra

American  

[suhb-stan-shee-uh nahy-gruh, nig-ruh] / səbˈstæn ʃi ə ˈnaɪ grə, ˈnɪg rə /

noun

• substantiae nigrae,
  plural
• substantia nigras
  plural

1. a deeply pigmented area of the midbrain containing dopamine-producing nerve cells.

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substantia nigra British  

/ səbˈstænʃə ˈnaɪɡrə /

noun

1. a layer of grey matter in the brain that produces dopamine and contains pigmented nerve cells, loss of which has been associated with Parkinson's disease

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Other Word Forms

Noun Inflected Forms

• substantia nigras
  plural
• substantiae nigrae
  plural

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Etymology

Origin of substantia nigra

1880–85; < New Latin: black substance

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Example Sentences

See Examples For:

substantia nigra

Among them were mGluR4 and NPDC1, two proteins found on dopamine producing neurons in the substantia nigra, the brain region most heavily affected by Parkinson's disease.

From Science Daily ● Jul. 12, 2026

In rodents exposed to TCE, the dopamine-generating neurons in the midbrain’s substantia nigra are destroyed, as happens in human Parkinson’s disease.

From Science Magazine ● May 15, 2023

It affects neurons in a specific area of the brain called the substantia nigra.

From BBC ● Mar. 31, 2022

“There are estrogen receptors on the substantia nigra, so women with higher estrogens might be somewhat protected,” Langston says.

From Washington Post ● Jul. 2, 2021

It is thought to depend upon some connexion, not yet anatomically demonstrated, between the third cranial nerve and its nucleus in the floor of the iter and the substantia nigra.

From The Project Gutenberg Encyclopedia Volume 1 of 28 by Project Gutenberg

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