syphilis

American  

[sif-uh-lis] / ˈsɪf ə lɪs /

noun

Pathology.

1. a chronic infectious disease, caused by a spirochete, Treponema pallidum, usually venereal in origin but often congenital, and affecting almost any organ or tissue in the body, especially the genitals, skin, mucous membranes, aorta, brain, liver, bones, and nerves.

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syphilis British  

/ ˈsɪfɪlɪs, ˌsɪfɪˈlɪtɪk /

noun

1. a venereal disease caused by infection with the microorganism Treponema pallidum: characterized by an ulcerating chancre, usually on the genitals and progressing through the lymphatic system to nearly all tissues of the body, producing serious clinical manifestations

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syphilis Scientific  

/ sĭf′ə-lĭs /

1. A sexually transmitted disease caused by the spirochete Treponema pallidum that is characterized in its primary stage by genital sores. If untreated, skin ulcers develop in the next stage, called secondary syphilis. As the disease progresses to potentially fatal tertiary syphilis, neurologic involvement with weakness and skeletal or cardiovascular damage can occur.

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syphilis Cultural  

1. A sexually transmitted disease caused by a microorganism. In its initial stages (called primary syphilis), it is manifested by a skin ulcer called a chancre. If the disease is not treated by penicillin or other antibiotics, the infection becomes chronic. In so-called tertiary syphilis, virtually any tissue in the body can be damaged, including the cardiovascular and nervous systems. The disease, if left untreated, can cause blindness, mental illness, and death.

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Other Word Forms

• syphilitic adjective
• syphilitically adverb
• syphiloid adjective

Etymology

Origin of syphilis

< New Latin, coined by Giovanni Fracastoro (1478–1553), Italian physician and poet, in his 1530 Latin poem Syphilis, sive morbus Gallicus (“Syphilis, or the French Disease”), an early account of syphilis

Example Sentences

This bacterium is responsible for several serious infectious diseases today, including syphilis.

From Science Daily • Jan. 26, 2026

Each causes a different disease: syphilis, yaws, and bejel.

From Science Daily • Jan. 26, 2026

Figures show that gay and bisexual men are disproportionately affected by STIs, accounting for 75% of syphilis and 70% gonorrhoea cases in London last year.

From BBC • Sep. 18, 2025

But the overall figure for syphilis, including what is called late-stage syphilis, or complications from the infection, rose 5% to 13,030.

From BBC • Jun. 3, 2025

The capacity to deal effectively with syphilis and tuberculosis represents a milestone in human endeavor, even though full use of this potential has not yet been made.

From "The Lives of a Cell" by Lewis Thomas

Related Words

• AIDS
• acquired immune deficiency syndrome
• gonorrhea
• herpes
• the clap
• venereal disease