TLS

abbreviation

1. Times Literary Supplement

Example Sentences

To test their idea, the team recreated the conditions of a TLS-rich tumor environment to identify which signals trigger TLS formation.

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Together, the researchers say, the findings suggest early and combined efforts to boost T-cell activity not only kill tumor cells directly but also induce TLS maturation that sustains and amplifies anti-tumor responses.

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"Our findings show that we can therapeutically induce functional TLS in otherwise immune-cold tumors," says Masanobu Komatsu, Ph.D., principal investigator of the study and senior scientist at the Johns Hopkins All Children's Cancer & Blood Disorders Institute.

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Because TLS abundance correlates with better outcomes across many tumor types, the use of the two protein stimulators together may offer a broadly applicable way to enhance the effectiveness of existing therapies, including checkpoint inhibitors that are the mainstay of immunotherapies, and traditional chemotherapy.

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Komatsu's team is further investigating the mechanism of action of TLS therapy and preparing for its clinical application in adult and pediatric cancer patients.

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