tolbutamide

American  

[tol-byoo-tuh-mahyd] / tɒlˈbyu təˌmaɪd /

noun

Pharmacology.

1. a white crystalline substance, C 12 H 18 N 2 O 3 S, used to augment insulin secretion in the treatment of diabetes mellitus.

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tolbutamide British  

/ tɒlˈbjuːtəˌmaɪd /

noun

1. a synthetic crystalline compound administered orally in the treatment of diabetes to lower blood glucose concentrations. Formula: C 12 H 18 N 2 O 3 S

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Etymology

Origin of tolbutamide

First recorded in 1955–60; tol(u) + but(yl) + amide

Example Sentences

As a result, the FDA recommended that tolbutamide be used only in cases in which the established treatments?dieting and insulin injections?had proved ineffective.

From Time Magazine Archive

The Food and Drug Administration jumped into a medical dispute this fall when it warned doctors to restrict their use of tolbutamide, an orally administered antidiabetes drug.

From Time Magazine Archive

Dr. Henry Dolger of Manhattan's Mount Sinai Hospital would have none of these fine distinctions, made a free-swinging attack on all the drugs except tolbutamide.

From Time Magazine Archive

For as long as 2� years, hundreds of thousands of diabetics all over the world have been treated with tablets of tolbutamide instead of insulin injections.

From Time Magazine Archive

Dr. Robert F. Bradley Jr. of Boston's famed Joslin Clinic, reporting on 1,000 patients intensively studied, said tolbutamide gave good control in 55% and fair control in 14%.

From Time Magazine Archive