tolbutamide

American

[tol-byoo-tuh-mahyd] / tɒlˈbyu təˌmaɪd /

noun

Pharmacology.

a white crystalline substance, C 12 H 18 N 2 O 3 S, used to augment insulin secretion in the treatment of diabetes mellitus.

tolbutamide British

/ tɒlˈbjuːtəˌmaɪd /

noun

a synthetic crystalline compound administered orally in the treatment of diabetes to lower blood glucose concentrations. Formula: C 12 H 18 N 2 O 3 S

"Collins English Dictionary — Complete & Unabridged" 2012 Digital Edition © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012

Etymology

Origin of tolbutamide

First recorded in 1955–60; tol(u) + but(yl) + amide

Example Sentences

Examples are provided to illustrate real-world usage of words in context. Any opinions expressed do not reflect the views of Dictionary.com.

Metformin reduced the risk of dying from heart attack and stroke by about 30 percent to 40 percent compared with other commonly used drugs called sulfonylureas, such as glibenclamide, glimepiride, glipizide and tolbutamide, researchers report.

From US News

The headline appeared almost exactly 35 years ago, on July 4, 1975, about a different drug for Type 2 diabetes that went through a strikingly similar controversy: tolbutamide.

From New York Times

Definitions and idiom definitions from Dictionary.com Unabridged, based on the Random House Unabridged Dictionary, © Random House, Inc. 2023