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transition mutation

n.
  1. A point mutation involving substitution of one base pair for another by replacement of one purine by another purine and of one pyrimidine by another pyrimidine but without change in the purine-pyrimidine orientation.
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.