tumor suppressor gene

American  

[toom-er-suh-pres-er jeen] / ˈtum ər səˈprɛs ər ˌdʒin /

noun

tumor suppressor genes plural

1. any of a group of genes that prevent uncontrolled cell division, unless the gene is rendered inactive through mutation.

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tumor suppressor gene Scientific  

1. A gene that suppresses cellular proliferation. When inherited in a mutated state in which it is no longer suppressive, it is associated with the development of various cancers, including most familial cancers.

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Other Word Forms

Noun Inflected Forms

• tumor suppressor genes
  plural

Example Sentences

See Examples For:

tumor suppressor gene

Additionally, it reveals the intricate connection between NMD and the most famous tumor suppressor gene, p53, suggesting possible new connections between NMD and cancer.

From Science Daily ● May 1, 2024

The collective function of the best- understood tumor suppressor gene proteins, Rb, p53, and p21, is to put up a roadblock to cell cycle progression until certain events are completed.

From Textbooks ● Jun. 9, 2022

"Is this a tumor suppressor gene? Is this an oncogene? Does it collaborate with gene XY? You can play the kind of games on the scale that you always wanted to," he says.

From Science Magazine ● Aug. 23, 2017

He hopes the project will help scientists develop a synthetic version of the tumor suppressor gene known as p53.

From Slate ● May 4, 2016

Research into HPV eventually uncovered how Henrietta’s cancer started: HPV inserted its DNA into the long arm of her eleventh chromosome and essentially turned off her p 5 3 tumor suppressor gene.

From "The Immortal Life of Henrietta Lacks" by Rebecca Skloot