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wheal-and-flare reaction

n.
  1. The characteristic immediate reaction to an injected allergen in a skin test, in which an irregular blanched wheal appears, surrounded by an area of redness.wheal-and-erythema reaction
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The American Heritage® Stedman's Medical Dictionary Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.