prime editing

American  

[prahym ed-it-ing] / ˈpraɪm ˌɛd ɪt ɪŋ /

noun

1. Genetics. a gene editing technique used to make targeted changes to DNA, replacing one DNA sequence with another through the use of a guide RNA that both targets the site and encodes the desired edit. The single edited strand of DNA is used by the cell to repair the other strand naturally.

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Example Sentences

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prime editing

Using their refined method, the MIT team lowered the rate of mistakes in prime editing from roughly one in seven edits to about one in 101 for the most common editing type.

From Science Daily ● Oct. 10, 2025

However, when the MIT team introduced those same mutations using the new prime editing technique, they found that the mutation prevented the tetramer from forming, allowing the cells to survive.

From Science Daily ● Mar. 12, 2024

Newer methods such as base editing and prime editing that avoid double-break strands may be safer.

From Science Magazine ● Mar. 12, 2023

Advances like prime editing didn’t yet exist in 2018, when Dr. He set out to edit human embryos in Shenzen.

From New York Times ● Jun. 27, 2022

Given that about 85% of disease-causing mutations in humans could, in theory, be corrected by prime editing, it clearly offers great promise.

From The Guardian ● Dec. 22, 2019