prime editing

American  

[prahym ed-it-ing] / ˈpraɪm ˌɛd ɪt ɪŋ /

noun

1. Genetics. a gene editing technique used to make targeted changes to DNA, replacing one DNA sequence with another through the use of a guide RNA that both targets the site and encodes the desired edit. The single edited strand of DNA is used by the cell to repair the other strand naturally.

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Example Sentences

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prime editing

To make the editors even more accurate, the researchers incorporated their new Cas9 proteins into a prime editing system that has an RNA binding protein that stabilizes the ends of the RNA template more efficiently.

From Science Daily ● Oct. 10, 2025

In 2019, Liu, who is also an author of the Nature Biotechnology study, developed a technique called prime editing, which enables any kind of point mutation to be introduced, as well as insertions and deletions.

From Science Daily ● Mar. 12, 2024

Newer methods such as base editing and prime editing that avoid double-break strands may be safer.

From Science Magazine ● Mar. 12, 2023

Advances like prime editing didn’t yet exist in 2018, when Dr. He set out to edit human embryos in Shenzen.

From New York Times ● Jun. 27, 2022

Given that about 85% of disease-causing mutations in humans could, in theory, be corrected by prime editing, it clearly offers great promise.

From The Guardian ● Dec. 22, 2019